Current
research suggests ovarian cancer begins in the fallopian tubes and
moves to the ovaries, the twin organs that produce a woman’s eggs and
the main source of the female hormones estrogen and progesterone.
Treatments for ovarian cancer have become more effective in recent
years, with the best results seen when the disease is found early.
The vast majority of ovarian cancers are
epithelial ovarian carcinomas. These are malignant tumours that form
from cells on the surface of the ovary. Some epithelial tumours are not
clearly cancerous. These are known as tumours of low malignant
potential. LMP tumours grow more slowly and are less dangerous than
other forms of ovarian cancer.
Ovarian cancer can be a frightening
diagnosis, with five-year relative survival rates that range from 89 per
cent to 18 per cent for epithelial ovarian cancer, depending on the
stage when the cancer was found. For LMP tumors, the five-year relative
survival rates range from 99 per cent to 77 per cent.
The symptoms of ovarian cancer include
bloating or pressure in the belly, pain in the abdomen or pelvis,
feeling full too quickly during meals, urinating more frequently.
However, women who have biological
children are less likely to get ovarian cancer than women who have never
given birth. The risk appears to decrease with every pregnancy, and
breastfeeding may offer added protection.
Ovarian cancer is also less common in
women who have taken birth control pills. Women who have used the pill
for at least five years have about half the risk of women who never took
the pill. Like pregnancy, birth control pills prevent ovulation. Some
researchers think ovulating less often may protect against ovarian
cancer.
Also, getting your tubes tied, formally
known as tubal ligation, may offer some protection against ovarian
cancer. The same goes for having a hysterectomy – removing the uterus.
For women with genetic mutations that
put them at high risk for ovarian cancer, removing the ovaries is an
option. This can also be considered in women over 40 getting a
hysterectomy.
While there is no definitive diet to
prevent ovarian cancer, there is evidence that what you eat can make a
difference. In one recent study, women who stuck to a low-fat diet for
at least four years were less likely to develop ovarian cancer. Some
researchers report the cancer is also less common in women who eat a lot
of vegetables.
Researchers are working on therapies
that target the way ovarian cancer grows. A process called angiogenesis
involves the formation of new blood vessels to feed tumors. A drug
called Avastin blocks this process, causing tumours to shrink or stop
growing. Avastin is approved for other cancers, but ovarian cancer
researchers are still testing this therapy, which can have serious side
effects.
Here are some factors that increase a woman’s chances of developing ovarian cancer
Family history
A woman’s odds of developing ovarian
cancer are higher if a close relative has had cancer of the ovaries,
breast, or colon. Researchers believe that inherited genetic changes
account for 10 per cent of ovarian cancers. This includes the BRCA1 and
BRCA2 gene mutations, which are linked to breast cancer. Women with a
strong family history should talk with a doctor to see whether closer
medical follow-up could be helpful.
Age
The strongest risk factor for ovarian
cancer is age. It’s most likely to develop after a woman goes through
menopause. Using postmenopausal hormone therapy may increase the risk.
The link seems strongest in women who take estrogen without progesterone
for at least five to 10 years. Doctors are not certain whether taking a
combination of estrogen and progesterone boosts the risk as well.
Obesity
Obese women have a higher risk of
getting ovarian cancer than other women. And the death rates for ovarian
cancer are higher for obese women too, compared with non-obese women.
The heaviest women appear to have the greatest risk.
After surgery
When women have both ovaries removed,
they can no longer produce their own estrogen. This triggers menopause,
no matter how young the patient. The drop in hormone levels can also
raise the risk for certain medical conditions, including osteoporosis.
It’s vital that women have regular follow-up care after being treated
for ovarian cancer.
Women may find that it takes a long time
for their energy to return after treatments end. Fatigue is a very
common problem after treatment for cancer. Beginning a gentle exercise
program is one of the most effective ways to restore energy and improve
emotional well-being. Check with your health care team to determine
which activities are right for after surgery.
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