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## **Erectile Dysfunction (ED)**
**Erectile Dysfunction (ED)** is the persistent inability to attain or maintain an erection sufficient for satisfactory sexual performance. It is a common medical condition that affects men of all ages but becomes more prevalent with advancing age. ED is not merely a sexual problem; it is often an early indicator of underlying systemic diseases.
### **Epidemiology**
Erectile dysfunction affects millions of men worldwide. Studies show that up to **50% of men over 40 years** experience some degree of ED, with prevalence increasing with age and the presence of chronic medical conditions.
### **Pathophysiology**
A normal erection requires the coordinated interaction of:
* Intact vascular supply
* Functional nerves
* Adequate hormonal levels
* Psychological readiness
Erectile dysfunction occurs when there is impairment in any of these mechanisms, particularly reduced penile blood flow, endothelial dysfunction, or disrupted neural signaling.
### **Causes of Erectile Dysfunction**
#### **Organic Causes**
* **Vascular disorders:** Hypertension, atherosclerosis, peripheral vascular disease
* **Endocrine disorders:** Diabetes mellitus, hypogonadism, hyperprolactinaemia, thyroid disorders
* **Neurological conditions:** Stroke, spinal cord injury, multiple sclerosis
* **Medications:** Antihypertensives, antidepressants, antipsychotics
* **Lifestyle factors:** Smoking, excessive alcohol use, obesity, physical inactivity
#### **Psychogenic Causes**
* Anxiety and depression
* Performance anxiety
* Relationship conflicts
* Stress and emotional trauma
*Many patients have a combination of organic and psychogenic factors.*
### **Clinical Presentation**
* Difficulty achieving or sustaining an erection
* Reduced rigidity or duration of erection
* Decreased sexual confidence
* Associated reduced libido or ejaculatory disorders
### **Diagnosis**
Evaluation of erectile dysfunction includes:
* Detailed medical, sexual, and psychosocial history
* Physical examination (cardiovascular, endocrine, and genital systems)
* Laboratory investigations:
* Fasting blood glucose
* Lipid profile
* Serum testosterone
* Prolactin and thyroid function tests (where indicated)
### **Management**
Treatment should be individualized and directed at the underlying cause.
#### **Lifestyle Modification**
* Smoking cessation
* Weight reduction
* Regular physical exercise
* Reduction of alcohol intake
* Optimal control of diabetes and hypertension
#### **Pharmacological Therapy**
* **Phosphodiesterase-5 inhibitors (PDE-5 inhibitors):**
* Sildenafil
* Tadalafil
* Vardenafil
* Avanafil
These drugs enhance erectile response by increasing penile blood flow and require sexual stimulation to be effective.
#### **Hormonal Therapy**
* Testosterone replacement therapy in confirmed hypogonadism
#### **Psychological Therapy**
* Counseling and cognitive-behavioral therapy for psychogenic ED
* Couples therapy where necessary
#### **Advanced Therapies**
* Vacuum erection devices
* Intracavernosal injections
* Penile prosthesis surgery (for refractory cases)
### **Prevention**
* Healthy lifestyle choices
* Early detection and treatment of chronic illnesses
* Regular medical check-ups
* Open communication with healthcare providers
### **Conclusion**
Erectile dysfunction is a treatable medical condition with significant physical and psychological implications. Early evaluation and appropriate management not only restore sexual function but may also prevent serious cardiovascular and metabolic complications.

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